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Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen

Liya Hu, Sue E. Crawford, Rita Czako, Nicolas W. Cortes-Penfield, David F. Smith, Jacques Le Pendu, Mary K. Estes and B. V. Venkataram Prasad ()
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Liya Hu: Verna and Marrs McLean, Baylor College of Medicine
Sue E. Crawford: Baylor College of Medicine, Houston, Texas 77030, USA
Rita Czako: Baylor College of Medicine, Houston, Texas 77030, USA
Nicolas W. Cortes-Penfield: Baylor College of Medicine, Houston, Texas 77030, USA
David F. Smith: Emory University School of Medicine
Jacques Le Pendu: NSERM, UMR892, Université de Nantes, 44007 Nantes, France
Mary K. Estes: Baylor College of Medicine, Houston, Texas 77030, USA
B. V. Venkataram Prasad: Verna and Marrs McLean, Baylor College of Medicine

Nature, 2012, vol. 485, issue 7397, 256-259

Abstract: This crystallographic study shows the attachment of human rotavirus VP8* to histo blood group A antigen, and suggests how changes within the structure of VP8* could allow switching from sialylated to non-sialylated glycan receptor.

Date: 2012
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DOI: 10.1038/nature10996

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