Systematic discovery of structural elements governing stability of mammalian messenger RNAs

Hani Goodarzi, Hamed S. Najafabadi, Panos Oikonomou, Todd M. Greco, Lisa Fish, Reza Salavati, Ileana M. Cristea and Saeed Tavazoie ()
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Hani Goodarzi: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Hamed S. Najafabadi: Institute of Parasitology, McGill University, Montreal, Quebec H3G1Y6, Canada
Panos Oikonomou: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Todd M. Greco: Princeton University
Lisa Fish: Laboratory of Systems Cancer Biology, Rockefeller University
Reza Salavati: Institute of Parasitology, McGill University, Montreal, Quebec H3G1Y6, Canada
Ileana M. Cristea: Princeton University
Saeed Tavazoie: Lewis-Sigler Institute for Integrative Genomics, Princeton University

Nature, 2012, vol. 485, issue 7397, 264-268

Abstract: Secondary structures, or pairing of complementary sequences within RNA, can regulate the binding of proteins that affect transcript stability, splicing, localization, and translation; a computational approach has now been used to discover secondary structures that affect global RNA stability through the binding of specific RNA binding proteins.

Date: 2012
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DOI: 10.1038/nature11013

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