Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Catherine C. Smith, Qi Wang, Chen-Shan Chin, Sara Salerno, Lauren E. Damon, Mark J. Levis, Alexander E. Perl, Kevin J. Travers, Susana Wang, Jeremy P. Hunt, Patrick P. Zarrinkar, Eric E. Schadt, Andrew Kasarskis, John Kuriyan and Neil P. Shah ()
Additional contact information
Catherine C. Smith: University of California
Qi Wang: University of California
Chen-Shan Chin: Pacific Biosciences
Sara Salerno: University of California
Lauren E. Damon: University of California
Mark J. Levis: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Alexander E. Perl: Abramson Cancer Center of the University of Pennsylvania
Kevin J. Travers: Pacific Biosciences
Susana Wang: Pacific Biosciences
Jeremy P. Hunt: Ambit Biosciences
Patrick P. Zarrinkar: Ambit Biosciences
Eric E. Schadt: Pacific Biosciences
Andrew Kasarskis: Pacific Biosciences
John Kuriyan: University of California
Neil P. Shah: University of California

Nature, 2012, vol. 485, issue 7397, 260-263

Abstract: Internal tandem duplication mutations in FLT3, known to be associated with a poor prognosis in acute myeloid leukaemia, are now shown to be a valid therapeutic target for the disease.

Date: 2012
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DOI: 10.1038/nature11016

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