Engineering the third wave of biocatalysis

U. T. Bornscheuer (), G. W. Huisman, R. J. Kazlauskas, S. Lutz, J. C. Moore and K. Robins
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U. T. Bornscheuer: Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Straße 4, D-17487 Greifswald, Germany
G. W. Huisman: Codexis Inc., 200 Penobscot Drive
R. J. Kazlauskas: Molecular Biology and Biophysics, Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, Saint Paul, Minnesota 55108, USA
S. Lutz: Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA
J. C. Moore: Merck Research Laboratories, Merck & Co.
K. Robins: Lonza AG, Valais Works, CH-3930 Visp, Switzerland

Nature, 2012, vol. 485, issue 7397, 185-194

Abstract: Abstract Over the past ten years, scientific and technological advances have established biocatalysis as a practical and environmentally friendly alternative to traditional metallo- and organocatalysis in chemical synthesis, both in the laboratory and on an industrial scale. Key advances in DNA sequencing and gene synthesis are at the base of tremendous progress in tailoring biocatalysts by protein engineering and design, and the ability to reorganize enzymes into new biosynthetic pathways. To highlight these achievements, here we discuss applications of protein-engineered biocatalysts ranging from commodity chemicals to advanced pharmaceutical intermediates that use enzyme catalysis as a key step.

Date: 2012
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DOI: 10.1038/nature11117

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