A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

Johan W. Jonker, Jae Myoung Suh, Annette R. Atkins, Maryam Ahmadian, Pingping Li, Jamie Whyte, Mingxiao He, Henry Juguilon, Yun-Qiang Yin, Colin T. Phillips, Ruth T. Yu, Jerrold M. Olefsky, Robert R. Henry, Michael Downes () and Ronald M. Evans ()
Additional contact information
Johan W. Jonker: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Jae Myoung Suh: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Annette R. Atkins: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Maryam Ahmadian: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Pingping Li: University of California at San Diego
Jamie Whyte: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Mingxiao He: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Henry Juguilon: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Yun-Qiang Yin: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Colin T. Phillips: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Ruth T. Yu: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Jerrold M. Olefsky: University of California at San Diego
Robert R. Henry: University of California at San Diego
Michael Downes: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Ronald M. Evans: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA

Nature, 2012, vol. 485, issue 7398, 391-394

Abstract: PPARγ induces fibroblast growth factor 1 to remodel visceral adipose tissue in response to a high-fat diet to maintain metabolic homeostasis.

Date: 2012
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DOI: 10.1038/nature10998

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