Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

Aaron A. Thompson, Wei Liu, Eugene Chun, Vsevolod Katritch, Huixian Wu, Eyal Vardy, Xi-Ping Huang, Claudio Trapella, Remo Guerrini, Girolamo Calo, Bryan L. Roth, Vadim Cherezov and Raymond C. Stevens ()
Additional contact information
Aaron A. Thompson: The Scripps Research Institute
Wei Liu: The Scripps Research Institute
Eugene Chun: The Scripps Research Institute
Vsevolod Katritch: The Scripps Research Institute
Huixian Wu: The Scripps Research Institute
Eyal Vardy: National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina Chapel Hill Medical School
Xi-Ping Huang: National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina Chapel Hill Medical School
Claudio Trapella: University of Ferrara, 44121 Ferrara, Italy
Remo Guerrini: University of Ferrara, 44121 Ferrara, Italy
Girolamo Calo: Section of Pharmacology and National Institute of Neuroscience, University of Ferrara, 44121 Ferrara, Italy
Bryan L. Roth: National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina Chapel Hill Medical School
Vadim Cherezov: The Scripps Research Institute
Raymond C. Stevens: The Scripps Research Institute

Nature, 2012, vol. 485, issue 7398, 395-399

Abstract: The crystal structure of the human nociceptin/orphanin FQ peptide receptor in complex with the peptide mimetic antagonist compound-24 is determined, with potential importance for the development of new therapeutic agents.

Date: 2012
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DOI: 10.1038/nature11085

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