The complex of tmRNA–SmpB and EF-G on translocating ribosomes

David J. F. Ramrath, Hiroshi Yamamoto, Kristian Rother, Daniela Wittek, Markus Pech, Thorsten Mielke, Justus Loerke, Patrick Scheerer, Pavel Ivanov, Yoshika Teraoka, Olga Shpanchenko, Knud H. Nierhaus and Christian M. T. Spahn ()
Additional contact information
David J. F. Ramrath: Institut für Medizinische Physik und Biophysik, Charite – Universitätsmedizin Berlin, Ziegelstrasse 5-9, 10117 Berlin, Germany
Hiroshi Yamamoto: Institut für Medizinische Physik und Biophysik, Charite – Universitätsmedizin Berlin, Ziegelstrasse 5-9, 10117 Berlin, Germany
Kristian Rother: Institute of Biology and Molecular Biotechnology, Collegium Biologicum, Adam Mickiewicz University, Ulica Umultowska 89, 61-614 Poznan, Poland
Daniela Wittek: Max Planck Institute for Molecular Genetics, AG Ribosomen, Ihnestrasse 73, 14195 Berlin, Germany
Markus Pech: Institut für Medizinische Physik und Biophysik, Charite – Universitätsmedizin Berlin, Ziegelstrasse 5-9, 10117 Berlin, Germany
Thorsten Mielke: Institut für Medizinische Physik und Biophysik, Charite – Universitätsmedizin Berlin, Ziegelstrasse 5-9, 10117 Berlin, Germany
Justus Loerke: Institut für Medizinische Physik und Biophysik, Charite – Universitätsmedizin Berlin, Ziegelstrasse 5-9, 10117 Berlin, Germany
Patrick Scheerer: Institut für Medizinische Physik und Biophysik, Charite – Universitätsmedizin Berlin, Ziegelstrasse 5-9, 10117 Berlin, Germany
Pavel Ivanov: Max Planck Institute for Molecular Genetics, AG Ribosomen, Ihnestrasse 73, 14195 Berlin, Germany
Yoshika Teraoka: Max Planck Institute for Molecular Genetics, AG Ribosomen, Ihnestrasse 73, 14195 Berlin, Germany
Olga Shpanchenko: Max Planck Institute for Molecular Genetics, AG Ribosomen, Ihnestrasse 73, 14195 Berlin, Germany
Knud H. Nierhaus: Institut für Medizinische Physik und Biophysik, Charite – Universitätsmedizin Berlin, Ziegelstrasse 5-9, 10117 Berlin, Germany
Christian M. T. Spahn: Institut für Medizinische Physik und Biophysik, Charite – Universitätsmedizin Berlin, Ziegelstrasse 5-9, 10117 Berlin, Germany

Nature, 2012, vol. 485, issue 7399, 526-529

Abstract: Stalled bacterial ribosomes can be rescued by interaction with SmpB protein and a highly structured transfer-messenger RNA, and a cryo-electron microscopy map of this complex now shows how EF-G-dependent translocation of this non-canonical ligand is facilitated by conformational changes in the ribosome and the transfer-messenger RNA.

Date: 2012
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DOI: 10.1038/nature11006

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