Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Ursula Fünfschilling, Lotti M. Supplie, Don Mahad, Susann Boretius, Aiman S. Saab, Julia Edgar, Bastian G. Brinkmann, Celia M. Kassmann, Iva D. Tzvetanova, Wiebke Möbius, Francisca Diaz, Dies Meijer, Ueli Suter, Bernd Hamprecht, Michael W. Sereda, Carlos T. Moraes, Jens Frahm, Sandra Goebbels and Klaus-Armin Nave ()
Additional contact information
Ursula Fünfschilling: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Lotti M. Supplie: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Don Mahad: Mitochondrial Research Group, Institute for Ageing and Health, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Susann Boretius: Biomedizinische NMR Forschungs GmbH am Max Planck Institute of Biophysical Chemistry, D-37070 Göttingen, Germany
Aiman S. Saab: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Julia Edgar: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Bastian G. Brinkmann: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Celia M. Kassmann: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Iva D. Tzvetanova: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Wiebke Möbius: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Francisca Diaz: University of Miami, Miller School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA
Dies Meijer: Erasmus MC, 3000 CA Rotterdam, Netherlands
Ueli Suter: Institute of Cell Biology, ETH Hönggerberg, Schafmattstrasse 18, 8093 Zürich, Switzerland
Bernd Hamprecht: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Michael W. Sereda: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Carlos T. Moraes: University of Miami, Miller School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA
Jens Frahm: Biomedizinische NMR Forschungs GmbH am Max Planck Institute of Biophysical Chemistry, D-37070 Göttingen, Germany
Sandra Goebbels: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
Klaus-Armin Nave: Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany

Nature, 2012, vol. 485, issue 7399, 517-521

Abstract: After myelination, oligodendrocytes are able to survive without mitochondrial respiration, suggesting that they can switch to aerobic glycolysis and release lactate.

Date: 2012
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DOI: 10.1038/nature11007

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