Melanoma genome sequencing reveals frequent PREX2 mutations

Michael F. Berger, Eran Hodis, Timothy P. Heffernan, Yonathan Lissanu Deribe, Michael S. Lawrence, Alexei Protopopov, Elena Ivanova, Ian R. Watson, Elizabeth Nickerson, Papia Ghosh, Hailei Zhang, Rhamy Zeid, Xiaojia Ren, Kristian Cibulskis, Andrey Y. Sivachenko, Nikhil Wagle, Antje Sucker, Carrie Sougnez, Robert Onofrio, Lauren Ambrogio, Daniel Auclair, Timothy Fennell, Scott L. Carter, Yotam Drier, Petar Stojanov, Meredith A. Singer, Douglas Voet, Rui Jing, Gordon Saksena, Jordi Barretina, Alex H. Ramos, Trevor J. Pugh, Nicolas Stransky, Melissa Parkin, Wendy Winckler, Scott Mahan, Kristin Ardlie, Jennifer Baldwin, Jennifer Wargo, Dirk Schadendorf, Matthew Meyerson, Stacey B. Gabriel, Todd R. Golub, Stephan N. Wagner, Eric S. Lander, Gad Getz, Lynda Chin () and Levi A. Garraway ()
Additional contact information
Michael F. Berger: The Broad Institute of Harvard and MIT
Eran Hodis: The Broad Institute of Harvard and MIT
Timothy P. Heffernan: Dana-Farber Cancer Institute
Yonathan Lissanu Deribe: Dana-Farber Cancer Institute
Michael S. Lawrence: The Broad Institute of Harvard and MIT
Alexei Protopopov: Dana-Farber Cancer Institute
Elena Ivanova: Dana-Farber Cancer Institute
Ian R. Watson: Dana-Farber Cancer Institute
Elizabeth Nickerson: The Broad Institute of Harvard and MIT
Papia Ghosh: Dana-Farber Cancer Institute
Hailei Zhang: Dana-Farber Cancer Institute
Rhamy Zeid: Dana-Farber Cancer Institute
Xiaojia Ren: Dana-Farber Cancer Institute
Kristian Cibulskis: The Broad Institute of Harvard and MIT
Andrey Y. Sivachenko: The Broad Institute of Harvard and MIT
Nikhil Wagle: Dana-Farber Cancer Institute
Antje Sucker: University Hospital Essen, D-45122 Essen, Germany
Carrie Sougnez: The Broad Institute of Harvard and MIT
Robert Onofrio: The Broad Institute of Harvard and MIT
Lauren Ambrogio: The Broad Institute of Harvard and MIT
Daniel Auclair: The Broad Institute of Harvard and MIT
Timothy Fennell: The Broad Institute of Harvard and MIT
Scott L. Carter: The Broad Institute of Harvard and MIT
Yotam Drier: Weizmann Institute of Science, Rehovot 76100, Israel
Petar Stojanov: The Broad Institute of Harvard and MIT
Meredith A. Singer: Dana-Farber Cancer Institute
Douglas Voet: The Broad Institute of Harvard and MIT
Rui Jing: The Broad Institute of Harvard and MIT
Gordon Saksena: The Broad Institute of Harvard and MIT
Jordi Barretina: The Broad Institute of Harvard and MIT
Alex H. Ramos: The Broad Institute of Harvard and MIT
Trevor J. Pugh: The Broad Institute of Harvard and MIT
Nicolas Stransky: The Broad Institute of Harvard and MIT
Melissa Parkin: The Broad Institute of Harvard and MIT
Wendy Winckler: The Broad Institute of Harvard and MIT
Scott Mahan: The Broad Institute of Harvard and MIT
Kristin Ardlie: The Broad Institute of Harvard and MIT
Jennifer Baldwin: The Broad Institute of Harvard and MIT
Jennifer Wargo: Massachusetts General Hospital
Dirk Schadendorf: University Hospital Essen, D-45122 Essen, Germany
Matthew Meyerson: The Broad Institute of Harvard and MIT
Stacey B. Gabriel: The Broad Institute of Harvard and MIT
Todd R. Golub: The Broad Institute of Harvard and MIT
Stephan N. Wagner: Allergy and Infectious Diseases, Medical University of Vienna and CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Eric S. Lander: The Broad Institute of Harvard and MIT
Gad Getz: The Broad Institute of Harvard and MIT
Lynda Chin: The Broad Institute of Harvard and MIT
Levi A. Garraway: The Broad Institute of Harvard and MIT

Nature, 2012, vol. 485, issue 7399, 502-506

Abstract: Whole-genome sequencing of 25 metastatic melanomas and matched germline DNA in humans reveals that the highest mutation load is associated with chronic sun exposure, and that the PREX2 gene is mutated in approximately 14 per cent of cases

Date: 2012
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature11071 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:485:y:2012:i:7399:d:10.1038_nature11071

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature11071

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().