Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Robert D. Bell, Ethan A. Winkler, Itender Singh, Abhay P. Sagare, Rashid Deane, Zhenhua Wu, David M. Holtzman, Christer Betsholtz, Annika Armulik, Jan Sallstrom, Bradford C. Berk and Berislav V. Zlokovic ()
Additional contact information
Robert D. Bell: Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center
Ethan A. Winkler: Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center
Itender Singh: Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center
Abhay P. Sagare: Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center
Rashid Deane: Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center
Zhenhua Wu: Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center
David M. Holtzman: Hope Center for Neurological Disorders, Knight Alzheimer’s Disease Research Center, Washington University School of Medicine
Christer Betsholtz: Karolinska Institutet, Stockholm SE-171 77, Sweden
Annika Armulik: Karolinska Institutet, Stockholm SE-171 77, Sweden
Jan Sallstrom: Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center
Bradford C. Berk: Aab Cardiovascular Research Institute, University of Rochester Medical Center
Berislav V. Zlokovic: Center for Neurodegenerative and Vascular Brain Disorders, University of Rochester Medical Center

Nature, 2012, vol. 485, issue 7399, 512-516

Abstract: The APOE4-mediated proinflammatory pathway is shown to initiate blood–brain barrier breakdown and resulting neurodegeneration in transgenic mice.

Date: 2012
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DOI: 10.1038/nature11087

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