Recurrent network activity drives striatal synaptogenesis

Yevgenia Kozorovitskiy, Arpiar Saunders, Caroline A. Johnson, Bradford B. Lowell and Bernardo L. Sabatini ()
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Yevgenia Kozorovitskiy: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA
Arpiar Saunders: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA
Caroline A. Johnson: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA
Bradford B. Lowell: Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Bernardo L. Sabatini: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA

Nature, 2012, vol. 485, issue 7400, 646-650

Abstract: Neurotransmitter release and activity are modulated in the striatum of mice to demonstrate that the balance of activity within the two antagonistic, inhibitory pathways co-mingled in this nucleus regulates excitatory innervation of the basal ganglia during development.

Date: 2012
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DOI: 10.1038/nature11052

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