Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development

Junke Zheng, Masato Umikawa, Changhao Cui, Jiyuan Li, Xiaoli Chen, Chaozheng Zhang, HoangDinh Huynh, Xunlei Kang, Robert Silvany, Xuan Wan, Jingxiao Ye, Alberto Puig Cantó, Shu-Hsia Chen, Huan-You Wang, E. Sally Ward and Cheng Cheng Zhang ()
Additional contact information
Junke Zheng: University of Texas Southwestern Medical Center
Masato Umikawa: University of Texas Southwestern Medical Center
Changhao Cui: University of Texas Southwestern Medical Center
Jiyuan Li: University of Texas Southwestern Medical Center
Xiaoli Chen: University of Texas Southwestern Medical Center
Chaozheng Zhang: University of Texas Southwestern Medical Center
HoangDinh Huynh: University of Texas Southwestern Medical Center
Xunlei Kang: University of Texas Southwestern Medical Center
Robert Silvany: University of Texas Southwestern Medical Center
Xuan Wan: University of Texas Southwestern Medical Center
Jingxiao Ye: University of Texas Southwestern Medical Center
Alberto Puig Cantó: University of Texas Southwestern Medical Center
Shu-Hsia Chen: Mount Sinai School of Medicine
Huan-You Wang: University of California San Diego
E. Sally Ward: University of Texas Southwestern Medical Center
Cheng Cheng Zhang: University of Texas Southwestern Medical Center

Nature, 2012, vol. 485, issue 7400, 656-660

Abstract: The binding of angiopoietin-like proteins to immune-inhibitory receptors maintains ‘stemness’ of haematopoietic stem cells and supports leukaemia development.

Date: 2012
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DOI: 10.1038/nature11095

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