Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

Alejandro A. Pezzulo, Xiao Xiao Tang, Mark J. Hoegger, Mahmoud H. Abou Alaiwa, Shyam Ramachandran, Thomas O. Moninger, Phillip H. Karp, Christine L. Wohlford-Lenane, Henk P. Haagsman, Martin van Eijk, Botond Bánfi, Alexander R. Horswill, David A. Stoltz, Paul B. McCray, Michael J. Welsh () and Joseph Zabner ()
Additional contact information
Alejandro A. Pezzulo: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Xiao Xiao Tang: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Mark J. Hoegger: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Mahmoud H. Abou Alaiwa: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Shyam Ramachandran: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Thomas O. Moninger: The Central Electron Microscopy Facility, Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Phillip H. Karp: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Christine L. Wohlford-Lenane: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Henk P. Haagsman: Faculty of Veterinary Medicine, Utrecht University, Utrecht 3584 CL, The Netherlands
Martin van Eijk: Faculty of Veterinary Medicine, Utrecht University, Utrecht 3584 CL, The Netherlands
Botond Bánfi: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Alexander R. Horswill: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
David A. Stoltz: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Paul B. McCray: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Michael J. Welsh: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
Joseph Zabner: Roy J. and Lucille A. Carver College of Medicine, University of Iowa

Nature, 2012, vol. 487, issue 7405, 109-113

Abstract: In a porcine cystic fibrosis model, lack of cystic fibrosis transmembrane conductance regulator (CFTR) is shown to result in acidification of airway surface liquid (ASL), and this decrease in pH reduces the ability of ASL to kill bacteria; the findings directly link loss of the CFTR anion channel to impaired defence against bacterial infection.

Date: 2012
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DOI: 10.1038/nature11130

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