Programmable single-cell mammalian biocomputers

Simon Ausländer, David Ausländer, Marius Müller, Markus Wieland and Martin Fussenegger ()
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Simon Ausländer: Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland
David Ausländer: Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland
Marius Müller: Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland
Markus Wieland: Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland
Martin Fussenegger: Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland

Nature, 2012, vol. 487, issue 7405, 123-127

Abstract: In synthetic biology, the use of regulatory proteins that bind either DNA or RNA to reprogram mammalian cellular functions allows a variety of computational ‘logic circuits’ to be built in a plug-and-play manner, which may pave the way for precise and robust control of future gene-based and cell-based therapies.

Date: 2012
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DOI: 10.1038/nature11149

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