The mutational landscape of lethal castration-resistant prostate cancer

Catherine S. Grasso, Yi-Mi Wu, Dan R. Robinson, Xuhong Cao, Saravana M. Dhanasekaran, Amjad P. Khan, Michael J. Quist, Xiaojun Jing, Robert J. Lonigro, J. Chad Brenner, Irfan A. Asangani, Bushra Ateeq, Sang Y. Chun, Javed Siddiqui, Lee Sam, Matt Anstett, Rohit Mehra, John R. Prensner, Nallasivam Palanisamy, Gregory A. Ryslik, Fabio Vandin, Benjamin J. Raphael, Lakshmi P. Kunju, Daniel R. Rhodes, Kenneth J. Pienta (), Arul M. Chinnaiyan () and Scott A. Tomlins
Additional contact information
Catherine S. Grasso: Michigan Center for Translational Pathology, University of Michigan Medical School
Yi-Mi Wu: Michigan Center for Translational Pathology, University of Michigan Medical School
Dan R. Robinson: Michigan Center for Translational Pathology, University of Michigan Medical School
Xuhong Cao: Michigan Center for Translational Pathology, University of Michigan Medical School
Saravana M. Dhanasekaran: Michigan Center for Translational Pathology, University of Michigan Medical School
Amjad P. Khan: Michigan Center for Translational Pathology, University of Michigan Medical School
Michael J. Quist: Michigan Center for Translational Pathology, University of Michigan Medical School
Xiaojun Jing: Michigan Center for Translational Pathology, University of Michigan Medical School
Robert J. Lonigro: Michigan Center for Translational Pathology, University of Michigan Medical School
J. Chad Brenner: Michigan Center for Translational Pathology, University of Michigan Medical School
Irfan A. Asangani: Michigan Center for Translational Pathology, University of Michigan Medical School
Bushra Ateeq: Michigan Center for Translational Pathology, University of Michigan Medical School
Sang Y. Chun: Michigan Center for Translational Pathology, University of Michigan Medical School
Javed Siddiqui: Michigan Center for Translational Pathology, University of Michigan Medical School
Lee Sam: Michigan Center for Translational Pathology, University of Michigan Medical School
Matt Anstett: Compendia Bioscience
Rohit Mehra: Michigan Center for Translational Pathology, University of Michigan Medical School
John R. Prensner: Michigan Center for Translational Pathology, University of Michigan Medical School
Nallasivam Palanisamy: Michigan Center for Translational Pathology, University of Michigan Medical School
Gregory A. Ryslik: Yale School of Public Health
Fabio Vandin: Brown University
Benjamin J. Raphael: Brown University
Lakshmi P. Kunju: Michigan Center for Translational Pathology, University of Michigan Medical School
Daniel R. Rhodes: Michigan Center for Translational Pathology, University of Michigan Medical School
Kenneth J. Pienta: Michigan Center for Translational Pathology, University of Michigan Medical School
Arul M. Chinnaiyan: Michigan Center for Translational Pathology, University of Michigan Medical School
Scott A. Tomlins: Michigan Center for Translational Pathology, University of Michigan Medical School

Nature, 2012, vol. 487, issue 7406, 239-243

Abstract: Exome sequencing is used to investigate the role of mutations and copy number aberrations in metastatic castration-resistant prostate cancer, revealing recurrent mutations in multiple chromatin/histone modifying genes, as well as genes involved in androgen signalling.

Date: 2012
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DOI: 10.1038/nature11125

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