An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

Rhys S. Allan (), Elina Zueva, Florence Cammas, Heidi A. Schreiber, Vanessa Masson, Gabrielle T. Belz, Danièle Roche, Christèle Maison, Jean-Pierre Quivy, Geneviève Almouzni and Sebastian Amigorena ()
Additional contact information
Rhys S. Allan: Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Elina Zueva: Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Florence Cammas: Institut de Recherche en Cancérologie de Montpellier, CRLC Val d’Aurelle-Paul Lamarque, 34298 Montpellier Cedex 5, France
Heidi A. Schreiber: Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Vanessa Masson: Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Gabrielle T. Belz: Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Danièle Roche: Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Christèle Maison: Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Jean-Pierre Quivy: Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Geneviève Almouzni: Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Sebastian Amigorena: Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France

Nature, 2012, vol. 487, issue 7406, 249-253

Abstract: The histone modification H3K9me3, the histone methyltransferase SUV39H1 and the H3K9me3-binding protein HP1α participate in maintaining the silent state of the two canonical T helper 1 cell signature genes (which encode interferon-γ and T-bet), ensuring T helper 2 lineage stability in vitro and in vivo; targeting this pathway has the potential to reduce asthma-related pathology.

Date: 2012
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DOI: 10.1038/nature11173

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