Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy
Tanmay A. M. Bharat,
Norman E. Davey,
Pavel Ulbrich,
James D. Riches,
Alex de Marco,
Michaela Rumlova,
Carsten Sachse,
Tomas Ruml and
John A. G. Briggs ()
Additional contact information
Tanmay A. M. Bharat: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Norman E. Davey: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Pavel Ulbrich: Institute of Chemical Technology, Prague, Technicka 3, 166 28 Prague, Czech Republic
James D. Riches: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Alex de Marco: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Michaela Rumlova: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of Czech Republic, v.v.i., Flemingovo nám. 2, 166 10 Prague, Czech Republic
Carsten Sachse: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Tomas Ruml: Institute of Chemical Technology, Prague, Technicka 3, 166 28 Prague, Czech Republic
John A. G. Briggs: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nature, 2012, vol. 487, issue 7407, 385-389
Abstract:
A hybrid cryo-electron microscopy/tomography approach is used to solve the structure of the immature Mason–Pfizer monkey virus Gag lattice at a resolution of 8 Å, allowing the derivation of a model for the structure of retroviral capsid in the immature Gag shell.
Date: 2012
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DOI: 10.1038/nature11169
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