Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

Magnus Manske, Olivo Miotto, Susana Campino, Sarah Auburn, Jacob Almagro-Garcia, Gareth Maslen, Jack O’Brien, Abdoulaye Djimde, Ogobara Doumbo, Issaka Zongo, Jean-Bosco Ouedraogo, Pascal Michon, Ivo Mueller, Peter Siba, Alexis Nzila, Steffen Borrmann, Steven M. Kiara, Kevin Marsh, Hongying Jiang, Xin-Zhuan Su, Chanaki Amaratunga, Rick Fairhurst, Duong Socheat, Francois Nosten, Mallika Imwong, Nicholas J. White, Mandy Sanders, Elisa Anastasi, Dan Alcock, Eleanor Drury, Samuel Oyola, Michael A. Quail, Daniel J. Turner, Valentin Ruano-Rubio, Dushyanth Jyothi, Lucas Amenga-Etego, Christina Hubbart, Anna Jeffreys, Kate Rowlands, Colin Sutherland, Cally Roper, Valentina Mangano, David Modiano, John C. Tan, Michael T. Ferdig, Alfred Amambua-Ngwa, David J. Conway, Shannon Takala-Harrison, Christopher V. Plowe, Julian C. Rayner, Kirk A. Rockett, Taane G. Clark, Chris I. Newbold, Matthew Berriman, Bronwyn MacInnis and Dominic P. Kwiatkowski ()
Additional contact information
Magnus Manske: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Olivo Miotto: MRC Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, UK
Susana Campino: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Sarah Auburn: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Jacob Almagro-Garcia: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Gareth Maslen: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Jack O’Brien: MRC Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, UK
Abdoulaye Djimde: Malaria Research and Training Centre, Faculty of Medicine, University of Bamako
Ogobara Doumbo: Malaria Research and Training Centre, Faculty of Medicine, University of Bamako
Issaka Zongo: Institut de Recherche en Sciences de la Santé, Direction Régionale de l’Ouést, Bobo-Dioulasso, Burkina Faso
Jean-Bosco Ouedraogo: Institut de Recherche en Sciences de la Santé, Direction Régionale de l’Ouést, Bobo-Dioulasso, Burkina Faso
Pascal Michon: Papua New Guinea Institute of Medical Research, Madang 511, Papua New Guinea
Ivo Mueller: Papua New Guinea Institute of Medical Research, Madang 511, Papua New Guinea
Peter Siba: Papua New Guinea Institute of Medical Research, Madang 511, Papua New Guinea
Alexis Nzila: KEMRI/Wellcome Trust Research Program
Steffen Borrmann: KEMRI/Wellcome Trust Research Program
Steven M. Kiara: KEMRI/Wellcome Trust Research Program
Kevin Marsh: KEMRI/Wellcome Trust Research Program
Hongying Jiang: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Xin-Zhuan Su: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Chanaki Amaratunga: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Rick Fairhurst: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Duong Socheat: Cambodia National Malaria Centre, Phnom Penh, Cambodia
Francois Nosten: Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University
Mallika Imwong: Faculty of Tropical Medicine, Mahidol University
Nicholas J. White: Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University
Mandy Sanders: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Elisa Anastasi: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Dan Alcock: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Eleanor Drury: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Samuel Oyola: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Michael A. Quail: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Daniel J. Turner: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Valentin Ruano-Rubio: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Dushyanth Jyothi: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Lucas Amenga-Etego: MRC Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, UK
Christina Hubbart: Wellcome Trust Centre for Human Genetics, University of Oxford
Anna Jeffreys: Wellcome Trust Centre for Human Genetics, University of Oxford
Kate Rowlands: Wellcome Trust Centre for Human Genetics, University of Oxford
Colin Sutherland: London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Cally Roper: London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Valentina Mangano: University of Rome ‘La Sapienza’
David Modiano: University of Rome ‘La Sapienza’
John C. Tan: The Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana 4655, USA
Michael T. Ferdig: The Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana 4655, USA
Alfred Amambua-Ngwa: MRC Laboratories
David J. Conway: London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Shannon Takala-Harrison: Centre for Vaccine Development, University of Maryland
Christopher V. Plowe: Centre for Vaccine Development, University of Maryland
Julian C. Rayner: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Kirk A. Rockett: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Taane G. Clark: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Chris I. Newbold: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Matthew Berriman: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Bronwyn MacInnis: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Dominic P. Kwiatkowski: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK

Nature, 2012, vol. 487, issue 7407, 375-379

Abstract: Next-generation sequencing is used here to analyse Plasmodium falciparum genome variation directly from clinical blood samples, as well as cultured isolates, from Africa, Asia and Oceania.

Date: 2012
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DOI: 10.1038/nature11174

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