Proto-genes and de novo gene birth

Anne-Ruxandra Carvunis, Thomas Rolland, Ilan Wapinski, Michael A. Calderwood, Muhammed A. Yildirim, Nicolas Simonis, Benoit Charloteaux, Cesar Hidalgo, Justin Barbette, Balaji Santhanam, Gloria A. Brar, Jonathan S. Weissman, Aviv Regev, Nicolas Thierry-Mieg, Michael E. Cusick and Marc Vidal ()
Additional contact information
Anne-Ruxandra Carvunis: Dana-Farber Cancer Institute
Thomas Rolland: Dana-Farber Cancer Institute
Ilan Wapinski: Harvard Medical School
Michael A. Calderwood: Dana-Farber Cancer Institute
Muhammed A. Yildirim: Center for International Development and Harvard University
Nicolas Simonis: Dana-Farber Cancer Institute
Benoit Charloteaux: Dana-Farber Cancer Institute
Justin Barbette: Dana-Farber Cancer Institute
Balaji Santhanam: Dana-Farber Cancer Institute
Gloria A. Brar: Howard Hughes Medical Institute, University of California, San Francisco, and California Institute for Quantitative Biosciences
Jonathan S. Weissman: Howard Hughes Medical Institute, University of California, San Francisco, and California Institute for Quantitative Biosciences
Aviv Regev: Broad Institute of MIT and Harvard
Nicolas Thierry-Mieg: UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Computational and Mathematical Biology Group, Grenoble F-38041, France
Michael E. Cusick: Dana-Farber Cancer Institute
Marc Vidal: Dana-Farber Cancer Institute

Nature, 2012, vol. 487, issue 7407, 370-374

Abstract: Novel protein-coding genes can arise either from pre-existing genes or de novo; here it is shown that functional genes emerge de novo through transitory proto-genes generated by widespread translational activity in non-genic sequences.

Date: 2012
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DOI: 10.1038/nature11184

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