SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

Marco Montagner, Elena Enzo, Mattia Forcato, Francesca Zanconato, Anna Parenti, Elena Rampazzo, Giuseppe Basso, Genesio Leo, Antonio Rosato, Silvio Bicciato, Michelangelo Cordenonsi and Stefano Piccolo ()
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Marco Montagner: University of Padua School of Medicine, Viale Colombo 3, 35131 Padua, Italy
Elena Enzo: University of Padua School of Medicine, Viale Colombo 3, 35131 Padua, Italy
Mattia Forcato: Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100 Modena, Italy
Francesca Zanconato: University of Padua School of Medicine, Viale Colombo 3, 35131 Padua, Italy
Anna Parenti: Section of Pathology, University of Padua, Viale Gabelli 2, 35126 Padua, Italy
Elena Rampazzo: Clinical and Experimental Hematology, University of Padova, Via Giustiniani 3, 35128 Padova, Italy
Giuseppe Basso: Clinical and Experimental Hematology, University of Padova, Via Giustiniani 3, 35128 Padova, Italy
Genesio Leo: Hospital San Bassiano, Via dei Lotti 40, 36061 Bassano del Grappa, Italy
Antonio Rosato: Oncology and Gastroenterology, and Istituto Oncologico Veneto IRCCS, Via Gattamelata 64, 35126 Padua, Italy
Silvio Bicciato: Center for Genome Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41100 Modena, Italy
Michelangelo Cordenonsi: University of Padua School of Medicine, Viale Colombo 3, 35131 Padua, Italy
Stefano Piccolo: University of Padua School of Medicine, Viale Colombo 3, 35131 Padua, Italy

Nature, 2012, vol. 487, issue 7407, 380-384

Abstract: SHARP1, which is itself regulated by the p63 metastasis suppressor, regulates the invasive and metastatic phenotype in triple-negative breast cancer (TNBC) through inhibition of hypoxia-inducible factors, and this process operates independently from oxygen levels.

Date: 2012
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DOI: 10.1038/nature11207

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