RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

Min Yu, David T. Ting, Shannon L. Stott, Ben S. Wittner, Fatih Ozsolak, Suchismita Paul, Jordan C. Ciciliano, Malgorzata E. Smas, Daniel Winokur, Anna J. Gilman, Matthew J. Ulman, Kristina Xega, Gianmarco Contino, Brinda Alagesan, Brian W. Brannigan, Patrice M. Milos, David P. Ryan, Lecia V. Sequist, Nabeel Bardeesy, Sridhar Ramaswamy, Mehmet Toner, Shyamala Maheswaran () and Daniel A. Haber ()
Additional contact information
Min Yu: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
David T. Ting: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Shannon L. Stott: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Ben S. Wittner: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Fatih Ozsolak: Helicos BioSciences Corporation, One Kendall Square
Suchismita Paul: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Jordan C. Ciciliano: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Malgorzata E. Smas: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Daniel Winokur: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Anna J. Gilman: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Matthew J. Ulman: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Kristina Xega: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Gianmarco Contino: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Brinda Alagesan: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Brian W. Brannigan: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Patrice M. Milos: Helicos BioSciences Corporation, One Kendall Square
David P. Ryan: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Lecia V. Sequist: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Nabeel Bardeesy: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Sridhar Ramaswamy: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Mehmet Toner: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Shyamala Maheswaran: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School
Daniel A. Haber: Massachusetts General Hospital Cancer Center, Center for Engineering in Medicine, Harvard Medical School

Nature, 2012, vol. 487, issue 7408, 510-513

Abstract: A new method allows the collection of circulating tumour cells (CTCs) despite their rarity; transcriptome sequencing of CTCs could allow identification of pathways involved in metastasis.

Date: 2012
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DOI: 10.1038/nature11217

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