ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

Tatsuo Hashimoto, Thomas Perlot, Ateequr Rehman, Jean Trichereau, Hiroaki Ishiguro, Magdalena Paolino, Verena Sigl, Toshikatsu Hanada, Reiko Hanada, Simone Lipinski, Birgit Wild, Simone M. R. Camargo, Dustin Singer, Andreas Richter, Keiji Kuba, Akiyoshi Fukamizu, Stefan Schreiber, Hans Clevers, Francois Verrey, Philip Rosenstiel () and Josef M. Penninger ()
Additional contact information
Tatsuo Hashimoto: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Thomas Perlot: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Ateequr Rehman: Institute of Clinical Molecular Biology, University of Kiel, Schittenhelmstrasse12, 24105 Kiel, Germany
Jean Trichereau: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Hiroaki Ishiguro: Yokohama City University Graduate School of Medicine and School of Medicine, 2360004 Yokohama, Japan
Magdalena Paolino: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Verena Sigl: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Toshikatsu Hanada: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Reiko Hanada: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Simone Lipinski: Institute of Clinical Molecular Biology, University of Kiel, Schittenhelmstrasse12, 24105 Kiel, Germany
Birgit Wild: Center of Ecology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
Simone M. R. Camargo: Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Dustin Singer: Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Andreas Richter: Center of Ecology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
Keiji Kuba: Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan
Akiyoshi Fukamizu: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan
Stefan Schreiber: Institute of Clinical Molecular Biology, University of Kiel, Schittenhelmstrasse12, 24105 Kiel, Germany
Hans Clevers: Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands
Francois Verrey: Institute of Physiology and Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Philip Rosenstiel: Institute of Clinical Molecular Biology, University of Kiel, Schittenhelmstrasse12, 24105 Kiel, Germany
Josef M. Penninger: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria

Nature, 2012, vol. 487, issue 7408, 477-481

Abstract: Mutations in angiotensin-converting enzyme 2 are shown to predispose mice to colitis as a consequence of neutral amino acid malabsorption and a change in the resident microbiota; these results could explain how protein malnutrition — affecting up to one billion people — leads to intestinal inflammation.

Date: 2012
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DOI: 10.1038/nature11228

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