Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

N. M. Archin, A. L. Liberty, A. D. Kashuba, S. K. Choudhary, J. D. Kuruc, A. M. Crooks, D. C. Parker, E. M. Anderson, M. F. Kearney, M. C. Strain, D. D. Richman, M. G. Hudgens, R. J. Bosch, J. M. Coffin, J. J. Eron, D. J. Hazuda and D. M. Margolis ()
Additional contact information
N. M. Archin: The University of North Carolina at Chapel Hill
A. L. Liberty: The University of North Carolina at Chapel Hill
A. D. Kashuba: The University of North Carolina at Chapel Hill
S. K. Choudhary: The University of North Carolina at Chapel Hill
J. D. Kuruc: The University of North Carolina at Chapel Hill
A. M. Crooks: The University of North Carolina at Chapel Hill
D. C. Parker: The University of North Carolina at Chapel Hill
E. M. Anderson: HIV Drug Resistance Program, NCI, NIH, Frederick, Maryland 21702, USA
M. F. Kearney: HIV Drug Resistance Program, NCI, NIH, Frederick, Maryland 21702, USA
M. C. Strain: VA San Diego Healthcare System and University of California San Diego
D. D. Richman: VA San Diego Healthcare System and University of California San Diego
M. G. Hudgens: The University of North Carolina at Chapel Hill
R. J. Bosch: Harvard School of Public Health
J. M. Coffin: HIV Drug Resistance Program, NCI, NIH, Frederick, Maryland 21702, USA
J. J. Eron: The University of North Carolina at Chapel Hill
D. J. Hazuda: Merck Research Laboratories
D. M. Margolis: The University of North Carolina at Chapel Hill

Nature, 2012, vol. 487, issue 7408, 482-485

Abstract: The latent HIV-1 reservoir represents a major barrier to curing patients with HIV-1 infection, and now in vivo evidence is presented that vorinostat can disrupt proviral latency of HIV-1.

Date: 2012
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DOI: 10.1038/nature11286

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