Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

Orit Rozenblatt-Rosen, Rahul C. Deo, Megha Padi, Guillaume Adelmant, Michael A. Calderwood, Thomas Rolland, Miranda Grace, Amélie Dricot, Manor Askenazi, Maria Tavares, Samuel J. Pevzner, Fieda Abderazzaq, Danielle Byrdsong, Anne-Ruxandra Carvunis, Alyce A. Chen, Jingwei Cheng, Mick Correll, Melissa Duarte, Changyu Fan, Mariet C. Feltkamp, Scott B. Ficarro, Rachel Franchi, Brijesh K. Garg, Natali Gulbahce, Tong Hao, Amy M. Holthaus, Robert James, Anna Korkhin, Larisa Litovchick, Jessica C. Mar, Theodore R. Pak, Sabrina Rabello, Renee Rubio, Yun Shen, Saurav Singh, Jennifer M. Spangle, Murat Tasan, Shelly Wanamaker, James T. Webber, Jennifer Roecklein-Canfield, Eric Johannsen, Albert-László Barabási, Rameen Beroukhim, Elliott Kieff, Michael E. Cusick, David E. Hill, Karl Münger, Jarrod A. Marto (), John Quackenbush (), Frederick P. Roth (), James A. DeCaprio () and Marc Vidal ()
Additional contact information
Orit Rozenblatt-Rosen: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Rahul C. Deo: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Megha Padi: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Guillaume Adelmant: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Michael A. Calderwood: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Thomas Rolland: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Miranda Grace: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Amélie Dricot: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Manor Askenazi: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Maria Tavares: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Samuel J. Pevzner: Dana-Farber Cancer Institute
Fieda Abderazzaq: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Danielle Byrdsong: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Anne-Ruxandra Carvunis: Dana-Farber Cancer Institute
Alyce A. Chen: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Jingwei Cheng: Dana-Farber Cancer Institute
Mick Correll: Center for Cancer Computational Biology (CCCB), Dana-Farber Cancer Institute
Melissa Duarte: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Changyu Fan: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Mariet C. Feltkamp: Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Scott B. Ficarro: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Rachel Franchi: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Brijesh K. Garg: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Natali Gulbahce: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Tong Hao: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Amy M. Holthaus: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Robert James: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Anna Korkhin: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Larisa Litovchick: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Jessica C. Mar: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Theodore R. Pak: University of Toronto and Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Sabrina Rabello: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Renee Rubio: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Yun Shen: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Saurav Singh: Harvard Medical School
Jennifer M. Spangle: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Murat Tasan: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Shelly Wanamaker: Dana-Farber Cancer Institute
James T. Webber: Harvard Medical School
Jennifer Roecklein-Canfield: Dana-Farber Cancer Institute
Eric Johannsen: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Albert-László Barabási: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Rameen Beroukhim: Brigham and Women’s Hospital, Harvard Medical School
Elliott Kieff: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Michael E. Cusick: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
David E. Hill: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Karl Münger: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Jarrod A. Marto: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
John Quackenbush: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Frederick P. Roth: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
James A. DeCaprio: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
Marc Vidal: Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute

Nature, 2012, vol. 487, issue 7408, 491-495

Abstract: Combining analysis of host proteome and transcriptome perturbations induced by tumour virus proteins with ongoing genome-wide studies of cancer facilitates the prioritization of cancer genes.

Date: 2012
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DOI: 10.1038/nature11288

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