Viral immune modulators perturb the human molecular network by common and unique strategies

Andreas Pichlmair, Kumaran Kandasamy, Gualtiero Alvisi, Orla Mulhern, Roberto Sacco, Matthias Habjan, Marco Binder, Adrijana Stefanovic, Carol-Ann Eberle, Adriana Goncalves, Tilmann Bürckstümmer, André C. Müller, Astrid Fauster, Cathleen Holze, Kristina Lindsten, Stephen Goodbourn, Georg Kochs, Friedemann Weber, Ralf Bartenschlager, Andrew G. Bowie, Keiryn L. Bennett, Jacques Colinge and Giulio Superti-Furga ()
Additional contact information
Andreas Pichlmair: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Kumaran Kandasamy: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Gualtiero Alvisi: Molecular Virology, Heidelberg University, 69120 Heidelberg, Germany
Orla Mulhern: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
Roberto Sacco: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Matthias Habjan: Innate Immunity Laboratory, Max Planck Institute of Biochemistry, 82152 Martinsried/Munich, Germany
Marco Binder: Molecular Virology, Heidelberg University, 69120 Heidelberg, Germany
Adrijana Stefanovic: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Carol-Ann Eberle: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Adriana Goncalves: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Tilmann Bürckstümmer: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
André C. Müller: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Astrid Fauster: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Cathleen Holze: Innate Immunity Laboratory, Max Planck Institute of Biochemistry, 82152 Martinsried/Munich, Germany
Kristina Lindsten: Karolinska Institutet, 17177 Stockholm, Sweden
Stephen Goodbourn: St George’s, University of London, London SW17 0RE, UK
Georg Kochs: University of Freiburg, 79104 Freiburg, Germany
Friedemann Weber: University of Freiburg, 79104 Freiburg, Germany
Ralf Bartenschlager: Molecular Virology, Heidelberg University, 69120 Heidelberg, Germany
Andrew G. Bowie: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland
Keiryn L. Bennett: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Jacques Colinge: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
Giulio Superti-Furga: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria

Nature, 2012, vol. 487, issue 7408, 486-490

Abstract: A systems approach provides a global perspective of the different strategies that viruses use to modulate the cellular innate immune response; this may be useful in the design of future viral intervention strategies.

Date: 2012
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DOI: 10.1038/nature11289

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