A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Thorlakur Jonsson, Jasvinder K. Atwal, Stacy Steinberg, Jon Snaedal, Palmi V. Jonsson, Sigurbjorn Bjornsson, Hreinn Stefansson, Patrick Sulem, Daniel Gudbjartsson, Janice Maloney, Kwame Hoyte, Amy Gustafson, Yichin Liu, Yanmei Lu, Tushar Bhangale, Robert R. Graham, Johanna Huttenlocher, Gyda Bjornsdottir, Ole A. Andreassen, Erik G. Jönsson, Aarno Palotie, Timothy W. Behrens, Olafur T. Magnusson, Augustine Kong, Unnur Thorsteinsdottir, Ryan J. Watts and Kari Stefansson ()
Additional contact information
Thorlakur Jonsson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Jasvinder K. Atwal: Genentech, 1 DNA Way
Stacy Steinberg: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Jon Snaedal: Landspitali University Hospital, 101 Reykjavik, Iceland
Palmi V. Jonsson: Landspitali University Hospital, 101 Reykjavik, Iceland
Sigurbjorn Bjornsson: Landspitali University Hospital, 101 Reykjavik, Iceland
Hreinn Stefansson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Patrick Sulem: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Daniel Gudbjartsson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Janice Maloney: Genentech, 1 DNA Way
Kwame Hoyte: Genentech, 1 DNA Way
Amy Gustafson: Genentech, 1 DNA Way
Yichin Liu: Genentech, 1 DNA Way
Yanmei Lu: Genentech, 1 DNA Way
Tushar Bhangale: Genentech, 1 DNA Way
Robert R. Graham: Genentech, 1 DNA Way
Johanna Huttenlocher: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Gyda Bjornsdottir: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Ole A. Andreassen: Ullevål University Hospital and Institute of Psychiatry, University of Oslo, N-0407 Oslo, Norway
Erik G. Jönsson: HUBIN project, Karolinska Institutet and Hospital, SE-171 76 Stockholm, Sweden
Aarno Palotie: University of Helsinki, 00014 Helsinki, Finland
Timothy W. Behrens: Genentech, 1 DNA Way
Olafur T. Magnusson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Augustine Kong: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Unnur Thorsteinsdottir: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland
Ryan J. Watts: Genentech, 1 DNA Way
Kari Stefansson: deCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland

Nature, 2012, vol. 488, issue 7409, 96-99

Abstract: A coding mutation in APP, the gene that encodes the amyloid-β precursor protein, is found to protect against Alzheimer’s disease and cognitive decline in the elderly without Alzheimer’s disease.

Date: 2012
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DOI: 10.1038/nature11283

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