Programmed elimination of cells by caspase-independent cell extrusion in C. elegans

Daniel P. Denning, Victoria Hatch and H. Robert Horvitz ()
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Daniel P. Denning: Massachusetts Institute of Technology
Victoria Hatch: Massachusetts Institute of Technology
H. Robert Horvitz: Massachusetts Institute of Technology

Nature, 2012, vol. 488, issue 7410, 226-230

Abstract: Cells programmed to die during C. elegans embryogenesis can be eliminated from the embryo and undergo apoptosis in the absence of caspase activity via an extrusion mechanism that depends on activation of the AMPK-related kinase PIG-1 by an LKB1-like kinase complex.

Date: 2012
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DOI: 10.1038/nature11240

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