Protein activity regulation by conformational entropy

Shiou-Ru Tzeng and Charalampos G. Kalodimos ()
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Shiou-Ru Tzeng: Rutgers University
Charalampos G. Kalodimos: Rutgers University

Nature, 2012, vol. 488, issue 7410, 236-240

Abstract: Some variants of the bacterial gene regulator CAP show marked differences in their affinity for DNA despite identical DNA-binding interfaces; NMR spectroscopy experiments now show that DNA binding is determined by the proteins’ internal dynamics over a broad range of timescales in a manner that cannot be predicted from the proteins’ ground-state structures.

Date: 2012
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DOI: 10.1038/nature11271

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