APJ acts as a dual receptor in cardiac hypertrophy

Maria Cecilia Scimia, Cecilia Hurtado, Saugata Ray, Scott Metzler, Ke Wei, Jianming Wang, Chris E. Woods, Nicole H. Purcell, Daniele Catalucci, Takeshi Akasaka, Orlando F. Bueno, George P. Vlasuk, Perla Kaliman, Rolf Bodmer, Layton H. Smith, Euan Ashley, Mark Mercola, Joan Heller Brown and Pilar Ruiz-Lozano ()
Additional contact information
Maria Cecilia Scimia: Sanford-Burnham Medical Research Institute
Cecilia Hurtado: Sanford-Burnham Medical Research Institute
Saugata Ray: Sanford-Burnham Medical Research Institute
Scott Metzler: School of Medicine, Stanford University
Ke Wei: Sanford-Burnham Medical Research Institute
Jianming Wang: Sanford-Burnham Medical Research Institute
Chris E. Woods: School of Medicine, Stanford University
Nicole H. Purcell: University of California
Daniele Catalucci: Biomedical and Genetic Research Institute, National Research Council, via Fantoli 16/15, 20138, Milan, Italy
Takeshi Akasaka: Sanford-Burnham Medical Research Institute
Orlando F. Bueno: Wyeth Pharmaceutical
George P. Vlasuk: Wyeth Pharmaceutical
Perla Kaliman: Institute of Biomedical Research, August Pi i Sunyer (IDIBAPS), E-08036 Barcelona, Spain
Rolf Bodmer: Sanford-Burnham Medical Research Institute
Layton H. Smith: Sanford-Burnham Medical Research Institute
Euan Ashley: School of Medicine, Stanford University
Mark Mercola: Sanford-Burnham Medical Research Institute
Joan Heller Brown: University of California
Pilar Ruiz-Lozano: Sanford-Burnham Medical Research Institute

Nature, 2012, vol. 488, issue 7411, 394-398

Abstract: APJ is shown to be a bifunctional receptor for both mechanical stretch and the endogenous peptide apelin, a finding that is important for the development of APJ agonists to treat heart failure.

Date: 2012
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DOI: 10.1038/nature11263

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