Activation of specific interneurons improves V1 feature selectivity and visual perception

Seung-Hee Lee, Alex C. Kwan, Siyu Zhang, Victoria Phoumthipphavong, John G. Flannery, Sotiris C. Masmanidis, Hiroki Taniguchi, Z. Josh Huang, Feng Zhang, Edward S. Boyden, Karl Deisseroth and Yang Dan ()
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Seung-Hee Lee: Helen Wills Neuroscience Institute, University of California
Alex C. Kwan: Helen Wills Neuroscience Institute, University of California
Siyu Zhang: Helen Wills Neuroscience Institute, University of California
Victoria Phoumthipphavong: Helen Wills Neuroscience Institute, University of California
John G. Flannery: Helen Wills Neuroscience Institute, University of California
Sotiris C. Masmanidis: Broad Fellows Program in Brain Circuitry, Kavli Nanoscience Institute, California Institute of Technology
Hiroki Taniguchi: Cold Spring Harbor Laboratory
Z. Josh Huang: Cold Spring Harbor Laboratory
Feng Zhang: Howard Hughes Medical Institute, Stanford University
Edward S. Boyden: Media Laboratory, Biological Engineering, Brain and Cognitive Sciences, and McGovern Institute, Massachusetts Institute of Technology
Karl Deisseroth: Howard Hughes Medical Institute, Stanford University
Yang Dan: Helen Wills Neuroscience Institute, University of California

Nature, 2012, vol. 488, issue 7411, 379-383

Abstract: Optogenetic activation of parvalbumin-expressing versus other classes of interneurons is found to have distinct effects on the response properties of individual and populations of excitatory cells, as well as on visual behaviour in awake mice, providing evidence that this specific interneuron subtype has a unique role in visual coding and perception.

Date: 2012
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DOI: 10.1038/nature11312

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