Chromatin organization is a major influence on regional mutation rates in human cancer cells

Benjamin Schuster-Böckler and Ben Lehner ()
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Benjamin Schuster-Böckler: EMBL-CRG Systems Biology Unit, CRG and UPF, Barcelona 08003, Spain
Ben Lehner: EMBL-CRG Systems Biology Unit, CRG and UPF, Barcelona 08003, Spain

Nature, 2012, vol. 488, issue 7412, 504-507

Abstract: Mutation rates in cancer genomes are closely related to chromatin organization, indicating that the arrangement of the genome into heterochromatin- and euchromatin-like domains may be a dominant influence on variation in regional mutation rate in human somatic cells.

Date: 2012
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DOI: 10.1038/nature11273

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