A restricted cell population propagates glioblastoma growth after chemotherapy

Jian Chen, Yanjiao Li, Tzong-Shiue Yu, Renée M. McKay, Dennis K. Burns, Steven G. Kernie and Luis F. Parada ()
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Jian Chen: University of Texas Southwestern Medical Center
Yanjiao Li: University of Texas Southwestern Medical Center
Tzong-Shiue Yu: University of Texas Southwestern Medical Center
Renée M. McKay: University of Texas Southwestern Medical Center
Dennis K. Burns: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Steven G. Kernie: University of Texas Southwestern Medical Center
Luis F. Parada: University of Texas Southwestern Medical Center

Nature, 2012, vol. 488, issue 7412, 522-526

Abstract: By using a GFP reporter protein expressed selectively in neural stem cells in a mouse model of glioblastoma, a small subset of GFP-positive glioma cells is shown to be responsible for re-growth of tumours after chemotherapy.

Date: 2012
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DOI: 10.1038/nature11287

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