Defining the mode of tumour growth by clonal analysis

Gregory Driessens, Benjamin Beck, Amélie Caauwe, Benjamin D. Simons () and Cédric Blanpain ()
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Gregory Driessens: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Benjamin Beck: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Amélie Caauwe: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium
Benjamin D. Simons: Cavendish Laboratory, J. J. Thomson Avenue, Cambridge CB3 0HE, UK
Cédric Blanpain: Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium

Nature, 2012, vol. 488, issue 7412, 527-530

Abstract: Using genetic lineage tracing, tumour cells are traced in vivo in an unperturbed solid tumour; in a carcinogen-induced papilloma mouse model, cells in these benign lesions are found to mirror the clonal hierarchy organization of normal tissue.

Date: 2012
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DOI: 10.1038/nature11344

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