Recurrent R-spondin fusions in colon cancer

Somasekar Seshagiri (), Eric W. Stawiski, Steffen Durinck, Zora Modrusan, Elaine E. Storm, Caitlin B. Conboy, Subhra Chaudhuri, Yinghui Guan, Vasantharajan Janakiraman, Bijay S. Jaiswal, Joseph Guillory, Connie Ha, Gerrit J. P. Dijkgraaf, Jeremy Stinson, Florian Gnad, Melanie A. Huntley, Jeremiah D. Degenhardt, Peter M. Haverty, Richard Bourgon, Weiru Wang, Hartmut Koeppen, Robert Gentleman, Timothy K. Starr, Zemin Zhang, David A. Largaespada, Thomas D. Wu and Frederic J. de Sauvage ()
Additional contact information
Somasekar Seshagiri: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Eric W. Stawiski: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Steffen Durinck: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Zora Modrusan: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Elaine E. Storm: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Caitlin B. Conboy: Cell Biology and Development, Masonic Cancer Center, University of Minnesota
Subhra Chaudhuri: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Yinghui Guan: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Vasantharajan Janakiraman: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Bijay S. Jaiswal: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Joseph Guillory: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Connie Ha: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Gerrit J. P. Dijkgraaf: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jeremy Stinson: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Florian Gnad: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Melanie A. Huntley: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jeremiah D. Degenhardt: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Peter M. Haverty: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Richard Bourgon: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Weiru Wang: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Hartmut Koeppen: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Robert Gentleman: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Timothy K. Starr: Gynecology & Women’s Health, Masonic Cancer Center, University of Minnesota
Zemin Zhang: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
David A. Largaespada: Cell Biology and Development, Masonic Cancer Center, University of Minnesota
Thomas D. Wu: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Frederic J. de Sauvage: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA

Nature, 2012, vol. 488, issue 7413, 660-664

Abstract: Exomes, transcriptomes and copy-number alterations in a sample of more than 70 primary human colonic tumours were analysed in an attempt to characterize the genomic landscape; in addition to finding alterations in genes associated with commonly mutated signalling pathways, recurrent gene fusions involving R-spondin family members were also found to occur in approximately 10% of colonic tumours, revealing a potential new therapeutic target.

Date: 2012
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DOI: 10.1038/nature11282

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