Novel role of PKR in inflammasome activation and HMGB1 release

Ben Lu (), Takahisa Nakamura, Karen Inouye, Jianhua Li, Yiting Tang, Peter Lundbäck, Sergio I. Valdes-Ferrer, Peder S. Olofsson, Thomas Kalb, Jesse Roth, Yongrui Zou, Helena Erlandsson-Harris, Huan Yang, Jenny P.-Y. Ting, Haichao Wang, Ulf Andersson, Daniel J. Antoine, Sangeeta S. Chavan, Gökhan S. Hotamisligil and Kevin J. Tracey ()
Additional contact information
Ben Lu: Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
Takahisa Nakamura: Harvard School of Public Health
Karen Inouye: Harvard School of Public Health
Jianhua Li: Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
Yiting Tang: Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, New York, New York 11030, USA
Peter Lundbäck: Karolinska Institute, Karolinska University Hospital, Stockholm S-17176, Sweden
Sergio I. Valdes-Ferrer: Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
Peder S. Olofsson: Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
Thomas Kalb: Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
Jesse Roth: Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
Yongrui Zou: Center for Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, New York, New York 11030, USA
Helena Erlandsson-Harris: Karolinska Institute, Karolinska University Hospital, Stockholm S-17176, Sweden
Huan Yang: Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
Jenny P.-Y. Ting: University of North Carolina at Chapel Hill
Haichao Wang: North Shore University Hospital
Ulf Andersson: Women’s and Children’s Health, Karolinska Institute, Karolinska University Hospital, Stockholm S-17176, Sweden
Daniel J. Antoine: MRC Centre for Drug Safety Science, University of Liverpool, Liverpool L69 3GE, UK
Sangeeta S. Chavan: Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
Gökhan S. Hotamisligil: Harvard School of Public Health
Kevin J. Tracey: Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA

Nature, 2012, vol. 488, issue 7413, 670-674

Abstract: Double-stranded RNA-dependent protein kinase (PKR) is shown to be a key regulator of the inflammasome; PKR is central for caspase-1 activation and the release of interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1) in response to a diverse range of stimuli.

Date: 2012
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DOI: 10.1038/nature11290

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