Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

Bon-Kyoung Koo, Maureen Spit, Ingrid Jordens, Teck Y. Low, Daniel E. Stange, Marc van de Wetering, Johan H. van Es, Shabaz Mohammed, Albert J. R. Heck, Madelon M. Maurice () and Hans Clevers ()
Additional contact information
Bon-Kyoung Koo: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Maureen Spit: University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
Ingrid Jordens: University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
Teck Y. Low: Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands
Daniel E. Stange: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Marc van de Wetering: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Johan H. van Es: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Shabaz Mohammed: Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands
Albert J. R. Heck: Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CH Utrecht, The Netherlands
Madelon M. Maurice: University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
Hans Clevers: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands

Nature, 2012, vol. 488, issue 7413, 665-669

Abstract: In vivo and in vitro studies show that the stem-cell E3 ubiquitin ligases RNF43 and ZNRF3 act as tumour suppressors in colorectal cancer models, and are involved in the negative regulation of the cancer-associated Wnt signalling pathway through limiting the cell-surface expression of Wnt receptors.

Date: 2012
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DOI: 10.1038/nature11308

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