IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Masato Sasaki, Christiane B. Knobbe, Joshua C. Munger, Evan F. Lind, Dirk Brenner, Anne Brüstle, Isaac S. Harris, Roxanne Holmes, Andrew Wakeham, Jillian Haight, Annick You-Ten, Wanda Y. Li, Stefanie Schalm, Shinsan M. Su, Carl Virtanen, Guido Reifenberger, Pamela S. Ohashi, Dwayne L. Barber, Maria E. Figueroa, Ari Melnick, Juan-Carlos Zúñiga-Pflücker and Tak W. Mak ()
Additional contact information
Masato Sasaki: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Christiane B. Knobbe: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Joshua C. Munger: School of Medicine and Dentistry, University of Rochester
Evan F. Lind: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Dirk Brenner: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Anne Brüstle: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Isaac S. Harris: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Roxanne Holmes: Sunnybrook Research Institute, University of Toronto, Toronto, Ontario M4N 3M5, Canada
Andrew Wakeham: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Jillian Haight: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Annick You-Ten: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Wanda Y. Li: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Stefanie Schalm: Agios Pharmaceuticals Incorporated
Shinsan M. Su: Agios Pharmaceuticals Incorporated
Carl Virtanen: University Health Network Microarray Center, Toronto, Ontario M5S 1A8, Canada
Guido Reifenberger: Heinrich Heine University, 40225 Düsseldorf, Germany
Pamela S. Ohashi: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada
Dwayne L. Barber: University of Toronto, Toronto, Ontario M5G 2C1, Canada
Maria E. Figueroa: University of Michigan
Ari Melnick: Weill Cornell Medical College, Cornell University
Juan-Carlos Zúñiga-Pflücker: Sunnybrook Research Institute, University of Toronto, Toronto, Ontario M4N 3M5, Canada
Tak W. Mak: The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada

Nature, 2012, vol. 488, issue 7413, 656-659

Abstract: Mutations in isocitrate dehydrogenases IDH1 and IDH2 are common in human gliomas and acute myeloid leukaemias; here, mice that carry the IDH1(R132H) mutation are described, in a new model that should help in investigating the links between mutant IDH1 and leukaemia.

Date: 2012
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DOI: 10.1038/nature11323

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