Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

Claudia A. Doege, Keiichi Inoue, Toru Yamashita, David B. Rhee, Skylar Travis, Ryousuke Fujita, Paolo Guarnieri, Govind Bhagat, William B. Vanti, Alan Shih, Ross L. Levine, Sara Nik, Emily I. Chen and Asa Abeliovich ()
Additional contact information
Claudia A. Doege: Taub Institute for Aging, Columbia University
Keiichi Inoue: Taub Institute for Aging, Columbia University
Toru Yamashita: Taub Institute for Aging, Columbia University
David B. Rhee: Taub Institute for Aging, Columbia University
Skylar Travis: Taub Institute for Aging, Columbia University
Ryousuke Fujita: Taub Institute for Aging, Columbia University
Paolo Guarnieri: Biomedical Informatics Shared Resources, Columbia University
Govind Bhagat: Taub Institute for Aging, Columbia University
William B. Vanti: Taub Institute for Aging, Columbia University
Alan Shih: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Ross L. Levine: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Sara Nik: Stony Brook University
Emily I. Chen: Stony Brook University
Asa Abeliovich: Taub Institute for Aging, Columbia University

Nature, 2012, vol. 488, issue 7413, 652-655

Abstract: Parp1 and Tet2 mediate essential epigenetic remodelling events in an early phase of induced pluripotent stem cell reprogramming, thus directing subsequent induction of the pluripotency loci.

Date: 2012
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DOI: 10.1038/nature11333

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