T cells become licensed in the lung to enter the central nervous system

Francesca Odoardi, Christopher Sie, Kristina Streyl, Vijay K. Ulaganathan, Christian Schläger, Dmitri Lodygin, Klaus Heckelsmiller, Wilfried Nietfeld, Joachim Ellwart, Wolfgang E. F. Klinkert, Claudio Lottaz, Mikhail Nosov, Volker Brinkmann, Rainer Spang, Hans Lehrach, Martin Vingron, Hartmut Wekerle, Cassandra Flügel-Koch and Alexander Flügel ()
Additional contact information
Francesca Odoardi: Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany
Christopher Sie: Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany
Kristina Streyl: Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
Vijay K. Ulaganathan: Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
Christian Schläger: Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany
Dmitri Lodygin: Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany
Klaus Heckelsmiller: Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
Wilfried Nietfeld: Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
Joachim Ellwart: Institute of Molecular Immunology, Helmholtz Zentrum München, 81377 Munich, Germany
Wolfgang E. F. Klinkert: Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
Claudio Lottaz: Institute for Functional Genomics, University of Regensburg, 93053 Regensburg, Germany
Mikhail Nosov: College of Medicine, Nursing and Health Sciences, Regenerative Medicine Institute, National Centre for Biomedical Engineering Science, National University of Ireland, County Galway, Ireland
Volker Brinkmann: Autoimmunity, Transplantation and Inflammation Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland
Rainer Spang: Institute for Functional Genomics, University of Regensburg, 93053 Regensburg, Germany
Hans Lehrach: Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
Martin Vingron: Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
Hartmut Wekerle: Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
Cassandra Flügel-Koch: Institute for Anatomy II, Friedrich Alexander University, 91054 Erlangen, Germany
Alexander Flügel: Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany

Nature, 2012, vol. 488, issue 7413, 675-679

Abstract: A Lewis rat model of experimental autoimmune encephalomyelitis is used to show that on their way to the CNS, encephalitogenic T-cell blasts are temporarily resident in the lung, where they reprogram their gene-expression profile and functional properties to enable them to transgress the blood–brain barrier into the CNS.

Date: 2012
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DOI: 10.1038/nature11337

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