Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice

Lisa S. Andersson, Martin Larhammar, Fatima Memic, Hanna Wootz, Doreen Schwochow, Carl-Johan Rubin, Kalicharan Patra, Thorvaldur Arnason, Lisbeth Wellbring, Göran Hjälm, Freyja Imsland, Jessica L. Petersen, Molly E. McCue, James R. Mickelson, Gus Cothran, Nadav Ahituv, Lars Roepstorff, Sofia Mikko, Anna Vallstedt, Gabriella Lindgren, Leif Andersson () and Klas Kullander
Additional contact information
Lisa S. Andersson: Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden
Martin Larhammar: Uppsala University, SE-75124 Uppsala, Sweden
Fatima Memic: Uppsala University, SE-75124 Uppsala, Sweden
Hanna Wootz: Uppsala University, SE-75124 Uppsala, Sweden
Doreen Schwochow: Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden
Carl-Johan Rubin: Uppsala University, SE-75123 Uppsala, Sweden
Kalicharan Patra: Uppsala University, SE-75124 Uppsala, Sweden
Thorvaldur Arnason: Faculty of Land and Animal Resources, The Agricultural University of Iceland, IS-311 Borgarnes, Iceland
Lisbeth Wellbring: Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden
Göran Hjälm: Uppsala University, SE-75123 Uppsala, Sweden
Freyja Imsland: Uppsala University, SE-75123 Uppsala, Sweden
Jessica L. Petersen: College of Veterinary Medicine, University of Minnesota
Molly E. McCue: College of Veterinary Medicine, University of Minnesota
James R. Mickelson: College of Veterinary Medicine, University of Minnesota
Gus Cothran: College of Veterinary Medicine and Biomedical Sciences, Texas A&M University
Nadav Ahituv: University of California San Francisco
Lars Roepstorff: Unit of Equine Studies, Swedish University of Agricultural Sciences, Uppsala, SE-75007 Sweden
Sofia Mikko: Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden
Anna Vallstedt: Uppsala University, SE-75124 Uppsala, Sweden
Gabriella Lindgren: Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden
Leif Andersson: Swedish University of Agricultural Sciences, SE-75124 Uppsala, Sweden
Klas Kullander: Uppsala University, SE-75124 Uppsala, Sweden

Nature, 2012, vol. 488, issue 7413, 642-646

Abstract: A premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses, and the Dmrt3 transcription factor is critical in the development of a coordinated locomotor network in mice, suggesting that it has an important role in configuring the spinal circuits that control stride.

Date: 2012
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DOI: 10.1038/nature11399

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