The long-range interaction landscape of gene promoters

Amartya Sanyal, Bryan R. Lajoie, Gaurav Jain and Job Dekker ()
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Amartya Sanyal: Program in Systems Biology, Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-0103, USA
Bryan R. Lajoie: Program in Systems Biology, Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-0103, USA
Gaurav Jain: Program in Systems Biology, Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-0103, USA
Job Dekker: Program in Systems Biology, Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-0103, USA

Nature, 2012, vol. 489, issue 7414, 109-113

Abstract: Chromosome conformation capture carbon copy (5C) is used to look at the relationships between functional elements and distal target genes in 1% of the human genome in three dimensions; the study describes numerous long-range interactions between promoters and distal sites that include elements resembling enhancers, promoters and CTCF-bound sites, their genomic distribution and complex interactions.

Date: 2012
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DOI: 10.1038/nature11279

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