Endogenous antigen tunes the responsiveness of naive B cells but not T cells

Julie Zikherman, Ramya Parameswaran and Arthur Weiss ()
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Julie Zikherman: Rosalind Russell Medical Research Center for Arthritis, University of California
Ramya Parameswaran: Rosalind Russell Medical Research Center for Arthritis, University of California
Arthur Weiss: Rosalind Russell Medical Research Center for Arthritis, University of California

Nature, 2012, vol. 489, issue 7414, 160-164

Abstract: Mature B cells encounter antigens during development that induce anergy or functional unresponsiveness; this large reservoir of dormant autoreactive B cells may serve as a pool of extended antibody specificity for purposes of protective immunity, as well as the source of pathogenic autoantibodies that characterize rheumatic diseases such as systemic lupus erythematosus.

Date: 2012
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DOI: 10.1038/nature11311

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