Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

Marcus Dühren- von Minden, Rudolf Übelhart, Dunja Schneider, Thomas Wossning, Martina P. Bach, Maike Buchner, Daniel Hofmann, Elena Surova, Marie Follo, Fabian Köhler, Hedda Wardemann, Katja Zirlik, Hendrik Veelken and Hassan Jumaa ()
Additional contact information
Marcus Dühren- von Minden: Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
Rudolf Übelhart: Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
Dunja Schneider: Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
Thomas Wossning: Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
Martina P. Bach: Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
Maike Buchner: University Medical Center Freiburg, 79106 Freiburg, Germany
Daniel Hofmann: Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
Elena Surova: Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
Marie Follo: University Medical Center Freiburg, 79106 Freiburg, Germany
Fabian Köhler: Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany
Hedda Wardemann: Max Planck Research Group Molecular Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
Katja Zirlik: University Medical Center Freiburg, 79106 Freiburg, Germany
Hendrik Veelken: Leiden University Medical Center, 2333 ZA Leiden, the Netherlands
Hassan Jumaa: Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany

Nature, 2012, vol. 489, issue 7415, 309-312

Abstract: B-cell receptor (BCR) signalling in chronic lymphocytic leukaemia (CLL) is found not to be dependent on exogenous antigens; instead, signalling may involve the binding of the BCR heavy-chain complementarity-determining region to self epitopes on the same receptor, a finding that may have important implications for understanding the pathogenesis of CLL and potential therapeutic approaches.

Date: 2012
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DOI: 10.1038/nature11309

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