Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

Yuji Shiba, Sarah Fernandes, Wei-Zhong Zhu, Dominic Filice, Veronica Muskheli, Jonathan Kim, Nathan J. Palpant, Jay Gantz, Kara White Moyes, Hans Reinecke, Benjamin Van Biber, Todd Dardas, John L. Mignone, Atsushi Izawa, Ramy Hanna, Mohan Viswanathan, Joseph D. Gold, Michael I. Kotlikoff, Narine Sarvazyan, Matthew W. Kay, Charles E. Murry () and Michael A. Laflamme ()
Additional contact information
Yuji Shiba: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Sarah Fernandes: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Wei-Zhong Zhu: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Dominic Filice: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Veronica Muskheli: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Jonathan Kim: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Nathan J. Palpant: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Jay Gantz: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Kara White Moyes: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Hans Reinecke: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Benjamin Van Biber: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Todd Dardas: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
John L. Mignone: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
Atsushi Izawa: Shinshu University, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan
Ramy Hanna: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
Mohan Viswanathan: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
Joseph D. Gold: Geron Corporation, 230 Constitution Drive
Michael I. Kotlikoff: College of Veterinary Medicine, Cornell University
Narine Sarvazyan: The George Washington University, 2300 I Street NW, Washington DC 20037 USA
Matthew W. Kay: The George Washington University, 2300 I Street NW, Washington DC 20037 USA
Charles E. Murry: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA
Michael A. Laflamme: Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, Washington 98109, USA

Nature, 2012, vol. 489, issue 7415, 322-325

Abstract: A guinea-pig model of cardiac injury is used to show that human embryonic stem-cell-derived cardiomyocyte grafts can electrically integrate into the injured heart, improving mechanical function and reducing spontaneous and induced ventricular tachycardia; this is a major step towards clinical adoption of cell replacement therapies for cardiovascular diseases using human cardiomyocytes.

Date: 2012
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DOI: 10.1038/nature11317

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