Stereocontrolled organocatalytic synthesis of prostaglandin PGF2α in seven steps

Graeme Coulthard, William Erb and Varinder K. Aggarwal ()
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Graeme Coulthard: School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, UK
William Erb: School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, UK
Varinder K. Aggarwal: School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, UK

Nature, 2012, vol. 489, issue 7415, 278-281

Abstract: A concise new synthesis of the most complex of the prostaglandins—diverse hormone-like chemical messengers—should make existing prostaglandin-based drugs cheaper and also facilitate other related syntheses.

Date: 2012
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DOI: 10.1038/nature11411

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