Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

David Vilchez, Leah Boyer, Ianessa Morantte, Margaret Lutz, Carsten Merkwirth, Derek Joyce, Brian Spencer, Lesley Page, Eliezer Masliah, W. Travis Berggren, Fred H. Gage and Andrew Dillin ()
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David Vilchez: Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Leah Boyer: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Ianessa Morantte: Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Margaret Lutz: Stem Cell Core, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Carsten Merkwirth: Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Derek Joyce: Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Brian Spencer: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Lesley Page: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Eliezer Masliah: University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
W. Travis Berggren: Stem Cell Core, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Fred H. Gage: Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Andrew Dillin: Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA

Nature, 2012, vol. 489, issue 7415, 304-308

Abstract: Human embryonic stem cells (hESCs) are shown to have high 26S/30S proteasome activity owing to increased expression of the 19S proteasome subunit PSMD11; FOXO4 regulates proteasome activity in hESCs by modulating PSMD11 expression, and the high proteasome activity decreases after induced differentiation.

Date: 2012
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DOI: 10.1038/nature11468

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