Genomic approaches to studying the human microbiota

George M. Weinstock ()
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George M. Weinstock: The Genome Institute, Washington University

Nature, 2012, vol. 489, issue 7415, 250-256

Abstract: Abstract The human body is colonized by a vast array of microbes, which form communities of bacteria, viruses and microbial eukaryotes that are specific to each anatomical environment. Every community must be studied as a whole because many organisms have never been cultured independently, and this poses formidable challenges. The advent of next-generation DNA sequencing has allowed more sophisticated analysis and sampling of these complex systems by culture-independent methods. These methods are revealing differences in community structure between anatomical sites, between individuals, and between healthy and diseased states, and are transforming our view of human biology.

Date: 2012
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DOI: 10.1038/nature11553

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