Genome-wide association study indicates two novel resistance loci for severe malaria

Christian Timmann (), Thorsten Thye, Maren Vens, Jennifer Evans, Jürgen May, Christa Ehmen, Jürgen Sievertsen, Birgit Muntau, Gerd Ruge, Wibke Loag, Daniel Ansong, Sampson Antwi, Emanuel Asafo-Adjei, Samuel Blay Nguah, Kingsley Osei Kwakye, Alex Osei Yaw Akoto, Justice Sylverken, Michael Brendel, Kathrin Schuldt, Christina Loley, Andre Franke, Christian G. Meyer, Tsiri Agbenyega, Andreas Ziegler and Rolf D. Horstmann
Additional contact information
Christian Timmann: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Thorsten Thye: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Maren Vens: Institute of Medical Biometry and Statistics, University at Lübeck, 23562 Lübeck, Germany
Jennifer Evans: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Jürgen May: Infectious Disease Epidemiology Group, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Christa Ehmen: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Jürgen Sievertsen: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Birgit Muntau: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Gerd Ruge: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Wibke Loag: Infectious Disease Epidemiology Group, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Daniel Ansong: School of Medical Sciences, Kwame Nkrumah University of Science and Technology
Sampson Antwi: School of Medical Sciences, Kwame Nkrumah University of Science and Technology
Emanuel Asafo-Adjei: School of Medical Sciences, Kwame Nkrumah University of Science and Technology
Samuel Blay Nguah: School of Medical Sciences, Kwame Nkrumah University of Science and Technology
Kingsley Osei Kwakye: School of Medical Sciences, Kwame Nkrumah University of Science and Technology
Alex Osei Yaw Akoto: School of Medical Sciences, Kwame Nkrumah University of Science and Technology
Justice Sylverken: School of Medical Sciences, Kwame Nkrumah University of Science and Technology
Michael Brendel: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Kathrin Schuldt: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Christina Loley: Institute of Medical Biometry and Statistics, University at Lübeck, 23562 Lübeck, Germany
Andre Franke: Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, 24105 Kiel, Germany
Christian G. Meyer: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Tsiri Agbenyega: School of Medical Sciences, Kwame Nkrumah University of Science and Technology
Andreas Ziegler: Institute of Medical Biometry and Statistics, University at Lübeck, 23562 Lübeck, Germany
Rolf D. Horstmann: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany

Nature, 2012, vol. 489, issue 7416, 443-446

Abstract: A genome-wide association study in Ghana, West Africa, to identify genetic variants associated with malaria pathogenesis reveals two previously unknown loci on chromosomes 1 and 16.

Date: 2012
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DOI: 10.1038/nature11334

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