Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses

Norihiro Yumoto, Natalie Kim and Steven J. Burden ()
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Norihiro Yumoto: Molecular Neurobiology Program, Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, 540 First Avenue, New York, New York, USA
Natalie Kim: Molecular Neurobiology Program, Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, 540 First Avenue, New York, New York, USA
Steven J. Burden: Molecular Neurobiology Program, Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, 540 First Avenue, New York, New York, USA

Nature, 2012, vol. 489, issue 7416, 438-442

Abstract: Lrp4 acts bidirectionally and coordinates synapse formation by binding agrin, activating MuSK and stimulating postsynaptic differentiation, and functioning in turn as a muscle-derived retrograde signal that is necessary and sufficient for presynaptic differentiation.

Date: 2012
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DOI: 10.1038/nature11348

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