A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

Bethany A. Buckley, Kirk B. Burkhart, Sam Guoping Gu, George Spracklin, Aaron Kershner, Heidi Fritz, Judith Kimble, Andrew Fire and Scott Kennedy ()
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Bethany A. Buckley: Laboratory of Genetics, University of Wisconsin-Madison
Kirk B. Burkhart: Laboratory of Genetics, University of Wisconsin-Madison
Sam Guoping Gu: Stanford University
George Spracklin: Laboratory of Genetics, University of Wisconsin-Madison
Aaron Kershner: Howard Hughes Medical Institute, University of Wisconsin-Madison
Heidi Fritz: Laboratory of Genetics, University of Wisconsin-Madison
Judith Kimble: Laboratory of Genetics, University of Wisconsin-Madison
Andrew Fire: Stanford University
Scott Kennedy: Laboratory of Genetics, University of Wisconsin-Madison

Nature, 2012, vol. 489, issue 7416, 447-451

Abstract: Double-stranded RNA interference (RNAi) in Caenorhabditis elegans is heritable; here a genetic screen for factors required for RNAi inheritance identifies the nuclear-localized Argonaute gene hrde-1, which acts in the germ cells of progeny to promote multigenerational inheritance of silencing and, also, germline immortality.

Date: 2012
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DOI: 10.1038/nature11352

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